Grid2

Enables PDZ domain binding activity and scaffold protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of postsynaptic density assembly. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and regulation of neuron apoptotic process. Located in dendritic spine and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; eye; genitourinary system; intestine; and spinal cord. Used to study autosomal recessive spinocerebellar ataxia 18. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Nov 2024]

该基因激活PDZ结构域结合活性和支架蛋白结合活性。参与多种过程，包括小脑颗粒细胞分化；通过质膜细胞粘附分子介导的同种细胞间粘附；以及突触后密度组装的调控。在化学突触传递、前脉冲抑制和神经元凋亡过程的调控等过程中发挥上游或内部作用。位于树突棘和突触后膜。是离子型谷氨酸受体复合体的一部分。在谷氨酸能突触、平行纤维与浦肯野细胞突触以及突触后密度膜中活跃。表达于大脑、眼睛、泌尿生殖系统、肠道和脊髓等多个结构中。被用于研究常染色体隐性脊髓小脑性共济失调18型。与常染色体隐性脊髓小脑性共济失调18型相关的人类同源基因。与人类GRID2（谷氨酸离子型受体δ型亚单位2）同源。[由基因组资源联盟提供，2024年11月]