ADNP controls early neural induction and inhibitory neurons differentiation in cortical brain organoids by repressing transcription, in complex with KDM1A and GTF2I, at regulatory transposable elements.

Here we collect bulk and single-cell omics data for the manuscript on ADNP and Helsmoortel-Van der Aa-Syndrome jointly led by L.Rizzuti, M. Pelicano de Almeida and A.Vitriolo, and jointly supervised by G. Testa and R. Poot.This dataset contains raw counts, peaks, differential expression, differential accessibility and GO enrichments for - RNA-seq from human-derived iPSC and NSC, bearing mutations or KO of ADNP- ADNP, CTCF, and histone mark ChIP-seq in control and mutant lines endogenously tagged at ADNP locus -single-cell multiomics data from cortical brain organoids of 6 control and 6 HVDAS lines