All outcome measures per group, time point and location.

Values are expressed as group means and corresponding standard errors. As the main finding sustained reperfusion was observed in anti-GPIb treated mice, whereas controls exhibited significant progression of hypoperfusion from 2 h to 24 h. In the cortex of the MCA territory, reperfusion significantly increased from 2 h to 24 h in anti-GPIb treated mice presumably related to a larger capacity of collateral blood flow as compared to the subcortex. In the subcortex of anti-GPIb treated mice, improved reperfusion as compared to controls was reflected by a significantly higher baseline CBF at 2 h. Sustained reperfusion both in the cortical and subcortical territory of the MCA was associated with a protection from cerebral infarction as evident by a low probability of infarction.