Comparative analysis of lincomycin and celesticetin biosynthetic gene clusters.

The genes coding for proteins with already confirmed/published functions are marked (C), the functions of other encoded proteins were assigned either according to sequence analysis combined with the prediction (P) in literature [14], or based on BLAST analysis only (S). The genes in bold were selected for further testing. For shared homologous genes (below the bold line) the percentage of mutual identity of encoded proteins is shown, for details see S1 Document. C8—octose; LIN—lincomycin; CEL—celesticetin;*)—the relevant function, biosynthetic step assignment and sequence identity value concern only the marked gene; MFS—major facilitator superfamily; salicylate—both biosynthesis and attachment of the salicylate unit; AS—biosynthesis of amino sugar; PPL—biosynthesis of PPLComparative analysis of lincomycin and celesticetin biosynthetic gene clusters.