Genome level reveals the probiotic supplementation can alleviate stress and anxiety symptoms in stressed adults

In view of the potential beneficial effect of probiotic therapy in improving mental health via modulating the gut brain axis and the desirable properties of L. plantarum P8, a 12 weeks randomized, double blind, and placebo controlled study was performed to evaluate the efficacy of L. plantarum P8 in stress and anxiety alleviation. Two self administered stress questionnaires; Depression, Anxiety and Stress Scale and clinical indicators show that L. plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults. Based on this phenotypic result, we further explored that supplementation with L. plantarum P8 that regulate intestinal microbiota and metabolism would contribute to the secretion and release of neurotransmitters.