Dynamics of m6A methylation in ISKNV and siniperca chuatsi cell Infected by ISKNV

Infectious spleen and kidney necrosis virus (ISKNV) is a highly virulent and rapidly transmittable fish virus, posing threats to a wide variety of freshwater and marine fish aquaculture. N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes, which plays a key role in viral infections and the immune system. However, it remains largely unknown in ISKNV and ISKNV-infected cells. Therefore, we aim to determine the effects of ISKNV on the m6A modification and gene expression of mandarin fish fry cells to clarify the mechanism of ISKNV infection response.