Supplement 5. A total of 36 mutations in 19S proteasome subunits out of 895 patients were identified in CoMMpass study. from CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma

The mutation profile of all proteasome subunits in the genomic sequences derived by whole exome sequencing of 895 patients in the IA10 release of the CoMMpass study (https://www.themmrf.org/). A total of 36 mutations in 19S proteasome subunits were identified (one patient has three PSMC5 mutations and one patient has two PSMD7 mutations).A total of 16 PSMC subunit mutations, were identified although none of them was in PSMC6.