Mapping the Evolution of T Cell States During Response and Resistance to Adoptive Cellular Therapy

We investigated single T cell transcriptional states that define donor lymphocyte infusion (DLI) response and resistance from cryopreserved bone marrow mononuclear cells from 15 patients with relapsed chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplant. By integrating bulk ATAC-seq data from sorted T cell populations from these bone marrow samples, we also defined gene regulatory networks that underlay these clusters.]]>
15 patients with relapse CML after T cell depleted allogeneic hematopoietic stem cell transplantation (allo-SCT) treated with CD8-depleted DLI + 2 non-relapsed controls]]>