Different expression profiles of mRNAs in preeclampsia and normal placenta (mRNA). Different expression profiles of mRNAs in preeclampsia and normal placenta (mRNA)

Preeclampsia (PE), which results from abnormal placentation, acts as a primary cause of maternal and neonatal morbidity and mortality. However, the cause of abnormal development of placenta remain poorly understood.Recently, it has been proposed that the genes that are differnetially expressed between PE and normal placenta tissues are associated with PE pathogenesis. To further elucidate the pathogenesis, we conducted transcriptional profiling of mRNA between PE and normal placenta tissues. Overall design: Placental biopsies were obtained during Caesarean section from both normotensive patients (n=3) and from those with pre-eclampsia (n = 3) (early onset type; earlier than 31 weeks gestation)