Gene expression from ErbB2-driven mamamry tumors (MMTV-NIC model) with beta 1 integrin KO, beta 3 integrin KO or beta 1/beta 3 double KO

In this study, we used conditional knockout and gene expression approaches to understand global molecular and transciptional changes due to ablation of each integrin subunit. Affymetrix MoGene-2_0-st-v1 gene chip Beta 1 integrin and/or beta 3 integrin were specifically deleted in the mammary epithelium of MMTV-NIC mice. Total RNA was collected from end-burden tumors (flash frozen) and subjected to microarray gene expression. Data acquisition was performed by Quebec Genome Inovative Centre, McGill University.