BALANCED INDELS
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
The invention pertains to the targeted alteration of a duplex DNA in a cell， whereby two site-specific nucleases generate an indel， such that the open reading frame is not altered after the second indel. The invention further pertains to the use of such nucleases for the targeted alteration of an open reading frame in duplex DNA and a kit of parts for use in a method of the invention. Using the method of the invention， novel plants were obtained having an improved herbicide resistance. The invention therefore also concerns plants having improved herbicide resistance due to the expression of an altered ALS protein. The invention pertains to the targeted alteration of a duplex DNA in a cell， whereby two site-specific nucleases generate an indel， such that the open reading frame is not altered after the second indel. The invention further pertains to the use of such nucleases for the targeted alteration of an open reading frame in duplex DNA and a kit of parts for use in a method of the invention. Using the method of the invention， novel plants were obtained having an improved herbicide resistance. The invention therefore also concerns plants having improved herbicide resistance due to the expression of an altered ALS protein.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
