A new monosubstituted phenol from mangrove-derived fungus <i>Diaporthe spinosa</i> ZMU-32-1

A new monosubstituted phenol, Diaphenol A (<b>1</b>), along with nine related analogues, 2-phenylethanol (<b>2</b>), (4-methoxyphenyl)acetic acid (<b>3</b>), 3-hydroxybenzyl alcohol (<b>4</b>), 1-phenyl-1,2-ethanediol (<b>5</b>), bungein A (<b>6</b>), 2-(4-hydroxyphenyl)ethyl acetate (<b>7</b>), hydroxyphenylacetic acid (<b>8</b>), tyrosol (<b>9</b>), and orcinol (<b>10)</b> were isolated from the mangrove-derived fungus <i>Diaporthe spinosa</i> ZMU-32-1. The chemical structures of these compounds were elucidated through comprehensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionisation mass spectrometry (HR-ESIMS), and by comparison with previously reported spectral data. The antifungal activity of compounds <b>1</b>–<b>10</b> was evaluated, among which compound <b>6</b> exhibited notable antifungal activity against <i>Bipolaris sorokiniana</i>, with a minimum inhibitory concentration (MIC) value of 80 μg/mL.