Cu(II)-based coordination polymers: structural determination and protective effect on myocardial ischemia-reperfusion injury by reducing inflammatory response

In this work, two Cu(II)-containing coordination polymers, namely, {[Cu2(L)2(dpyb)(H2O)4]·6H2O}n (1) and {[Cu2(L)2(dpyb)](CH3CN)2}n (2) have been hydrothermally synthesized based on a substituted thiophene carboxylic acid 3,3′-(thiophene-2,5-diyl)dibenzoic acid (H2L) and auxiliary N-donor co-ligand 1,4-di(pyridin-4-yl)benzene (dpyb). Furthermore, the protective effect of compounds 1 and 2 on myocardial ischemia-reperfusion injury (MIRI) was evaluated and the specific was explored. The real-time reverse transcription-polymerase chain reaction (RT-PCR) revealed the down-regulated relative expression of the nf-κb and mapk genes after compound treatment. The enzyme-linked immunosorbent assay (ELISA) suggested the inhibitory of the compound on inflammatory cytokines IL1-β and TNF-α releasing.