Associations at novel loci for incident CHD in African Americans: discovery and replication.

CI, confidence interval; HR, hazard ratio; MAF, minor allele frequency; N, number; SNP, single nucleotide polymorphism. MAF for SNPs in HapMap CEU samples are: rs2070583 G allele = 0.009, rs4645948 T allele = 0.027 and rs1965328 A allele = 0.265.P for between-study heterogeneity was not significant. SNPs were eligible for replication if P−5. The array wide significant threshold is P−7. Replication was considered a PP less than discovery in the combined discovery and replication samples. Note CHD events do not include procedures.* Atherosclerosis Risk in Communities study and Women's Health Initiative study; † Additional samples from Women's Health Initiative, GeneSTAR and Health ABC studies; #CHARGE Consortium.Associations at novel loci for incident CHD in African Americans: discovery and replication.