Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth. Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA475425
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We performed RNA-seq of MDA-MB-231 cells that were treated with MS645 or JQ1 at 50 nM and 500 nM in an effort to understand how MS645 exerts such a profound cell growth inhibition on cancer cells. Overall design: MDA-MB-231 cells were treated with DMSO and different concentrations of JQ1 and MS645 for 18 hrs to compare the compounds' effect in transcriptional regulation.
创建时间:
2018-06-10



