Insulin-like Growth Factor Binding Protein-7 (IGFBP7) regulation in Hepatocellular Carcinoma

Insulin like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). We profiled genome-wide gene expression of Igfbp7 knockout (Igfbp7-/-) mouse to demonstrate the constitutive activation of IGF signaling and its relationship to the accelerated carcinogen-induced HCC. Overall design: Three replicates of RNAs derived from WT and IGFBP7-KO adult liver tissues were prepared for RNA-seq libraries and differential expression analysis were performed.