NR1H2,3 binds the APOC4 gene

Apolipoprotein C4 (APOC4) is present in the APOE, APOC1, APOC4 and APOC2-gene cluster which is induced by natural and synthetic ligands of liver X receptors (LXRα, NR1H3 and LXRβ, NR1H2) in both human and mouse macrophages (Mak PA et al. 2002). The induction of all four mRNAs was greatly attenuated in macrophages derived from LXR α/β-/- mice (Mak PA et al. 2002). Cell reporter assays suggest that the LXR response elements (LXRE) in the multienhancer regions ME.1 and ME.2, which confer tissue-specific expression in macrophages and adipocytes (Shih SJ et al. 2000), are necessary for the expression of this gene cluster (Mak PA et al. 2002). These secreted apolipoproteins regulate lipid transport and catabolism.

载脂蛋白C4（APOC4）存在于APOE、APOC1、APOC4及APOC2基因簇中，该基因簇由肝脏X受体（LXRα、NR1H3和LXRβ、NR1H2）的自然和合成配体在人类和小鼠巨噬细胞（Mak PA等，2002年）中诱导而成。在LXR α/β-/-小鼠来源的巨噬细胞中，所有四种mRNA的诱导作用均显著减弱（Mak PA等，2002年）。细胞报告实验表明，多增强子区域ME.1和ME.2中的LXR反应元件（LXRE），这些元件赋予巨噬细胞和脂肪细胞组织特异性表达（Shih SJ等，2000年），对于该基因簇的表达是必要的（Mak PA等，2002年）。这些分泌型载脂蛋白调节脂质运输和代谢。