Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression [Circular RNAs]

Circular RNAs (circRNAs) represent critical roles in the biology of various cancers. However, their expression patterns and biological functions in human colorectal cancer (CRC) remain largely unknown. The aim of this study was to explore circRNAs profiles in CRC and investigate key circRNAs involved in CRC tumourigenesis and progression. To detect the circRNAs expression profiles in 10 colrectal cancer (CRC) tissues and their corresponding normal-appearing tissues (NATs) by human circRNA expression profile chips and to identify the differentially expressed circRNAs between CRC and their corresponding NATs based on the chip data. In this way, this study provided the basis for identifying novel CRC biomarkers and further studying the roles and functions of differentially expressed circRNAs in CRC. The function of the differentially expressed circRNAs were analyzed by bioinformatic methods.