Targeting p160 SRCs in prostate cancer with bufalin (1)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147172
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资源简介：
The p160 Steroid Receptor Coactivators SRC-1, SRC-2, and SRC-3 are critical components of the AR transcriptional complex and are frequently upregulated in prostate cancer (PC). We showed that inhibition of the SRCs via a small molecule inhibitor significantly diminishes AR signaling output, expression of CRPC-associated transcripts and proliferation of CRPC cells both in vitro and in vivo. LNCaP cells and LNCaP-abl (Abl) cells were treated with 10 nM bufalin or control for 48h.
创建时间：
2025-03-15
