Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential early diagnosis biomarkers for colorectal carcinoma. Homo sapiens

DNA methylation abnormal is the hallmark of human cancers and was demonstrated to be most promising biomarker for early diagnosis to human cancers. However, majority of DNA methylation biomarkers were identified by the hypothesis that early differential methylation regions (DMRs) are maintained and could be detected in all stage of cancers. In this study, we applied Illumina methylation 450K beadchip to identify colorectal cancer early diagnostic biomarkers based on pre-colorectal cancer samples including low-grade and high-grade adenoma (N=60). We identified that 209 and 8692 CpG sites were significantly hyper-methylated in the low-grade adenoma (LGA) and high-grade adenoma (HGA), respectively.