Asymmetric Synthesis of Fluorinated Amino Macrolactones through Ring-Closing Metathesis

The synthesis of new chiral fluorinated amino and azamacrolactones of types 1 and 2 is described. A
ring-closing metathesis (RCM) reaction constitutes the key step in this methodology, which uses fluorinated
amino alcohols 7 as starting materials. The influence of the CF2 group, which is located in the α-position
relative to the carbon bearing the amino group, on the efficiency of the RCM reaction is noteworthy.
This method allows for the preparation of the desired fluorinated macrolactones in excellent yields.