Dataset related to article:LONGITUDINAL AND COMBINED ASSESSMENT OF 24(S)-HYDROXYCHOLESTEROL AND NEUROFILAMENT LIGHT CHAIN IN THE EARLY STAGES OF HUNTINGTON'S DISEASE

OUR DATABASE CONTAINS EPIDEMIOLOGICAL, CLINICAL, NEUROIMAGING AND LABORATORY LONGITUDINAL DATA COLLECTED FROM PATIENTS WITH HUNTINGTON'S DISEASE (HD) AND CONTROL SUBJECTS. EACH INDIVIDUAL IS IDENTIFIED THROUGH AN ANONYMIZED ID. OUR DATABASE IS DESIGNED TO TRACK DISEASE PROGRESSION, METABOLIC BIOMARKERS AND BRAIN VOLUMETRIC CHANGES OVER TIME (FROM BASELINE/T0 TO FOLLOW-UP/T1). METABOLIC BIOMARKES DATA AVAILABLE: BASELINE AND FOLLOW-UP VALUES TOTAL CHOLESTEROL, NEUROFILAMENT LIGHT CHAIN (NFL), 7-DEHYDROXY-CHOLESTEROL (7DHC), DESMOSTEROL, 27-HYDROXYCHOLESTEROL AND THE 24-HYDROXYCHOLESTEROL (24SOHC). EPIDEMIOLOGICAL DATA PROVIDED: BASELINE AND FOLLOW-UP DATES AND AGE AT BASELINE AND DISEASE ONSET, DISEASE DURATION. CLINICAL DATA INCLUDED: BASELINE AND FOLLOW-UP HD-ISS STAGE, UHDRS, SDMT, MMSE, STROOP TEST, TMT. NEUROIMAGING DATA AVAILABLE: BASELINE AND FOLLOW-UP TOTAL INTRACRANIAL VOLUME (TIV) OF BRAINSTEM, CORTICAL REGIONS (OCCIPITAL, CINGULATE, FRONTAL, TEMPORAL, PARIETAL AND CEREBELLAR CORTEX) AND SUBCORTICAL REGIONS (PUTAMEN, CAUDATE, PALLIDUM, THALAMUS, AND ACCUMBENS).