IRF8-dependent control of pDC terminal differentiation and MYC repression. IRF8-dependent control of pDC terminal differentiation and MYC repression

A switch from MYC expression in bone marrow progenitors to MYCL expression in terminal dendrtitic cell (DC) subsets occurs during DC development. The present study identifies the precise stage during DC development when this switch occurs, and identifies a role for IRF8 in control of this switch. IRF8 is found to be required for both MYC repression and MYCL induction during DC specification in vivo. Overall design: Splenic pDCs were isolated from WT and IRF8-deficient mice for expression microarray analysis.