The effects of PaPE-1 on amyloid beta-induced autophagy changes

Data related to the article "Non-nuclear Estrogen Receptor Signaling as a Promising Therapeutic Target to Reverse Alzheimer's Disease-related Autophagy Deficits and Upregulate the Membrane ESR1 and ESR2 Which Involves DNA Methylation-dependent Mechanisms" J Mol Biol. Published online February 4, 2025. doi:10.1016/j.jmb.2025.168982. We aimed to verify the neuroprotective capacity of PaPE-1 against amyloid beta (Aβ)-induced toxicity.  Fig 1 –  MAP-2 immunofluorescent staining; Fig 2 –  caspase-3 activity, autophagosome formation and cytoID staining; Fig 3 –  autophagy-related proteins, mRNAs and DNA methylation; Fig 4 – the impact of estrogen receptors antagonists; Fig 5 –  estrogen receptors proteins, mRNAs and DNA methylation; Fig 6 – estrogen receptors-related proteins, mRNAs and DNA methylation; Fig 7 –  global DNA methylation, HAT and HDAC activities.