Data from: Trends in incidence and epidemiological characteristics of cerebral venous thrombosis in the United States

Objective To test the hypothesis that racial-, age- and sex-specific
incidence of cerebral venous thrombosis (CVT) has increased in the United
States over the last decade. Methods In this retrospective cohort study,
validated International Classification of Disease codes were used to
identify all new cases of CVT (n=5,567) in the State Inpatients Database
(SID) of New York and Florida (2006-2016). A new CVT case was defined as
first hospitalization for CVT in the SID without prior CVT
hospitalization. CVT counts were combined with annual Census data to
compute incidence. Joinpoint regression was used to evaluate trends in
incidence over time. Results From 2006-2016, annual age and
sex-standardized incidence of CVT in cases/million population ranged from
13.9-20.2, but incidence varied significantly by sex (females: 20.3-26.9;
males 6.8-16.8) and by age/sex (females 18-44yo: 24.0-32.6%; males:
18-44yo: 5.3-12.8). Incidence also differed by race (Blacks:18.6-27.2;
Whites: 14.3-18.5; Asians: 5.1-13.8). On joinpoint regression, incidence
increased across 2006-2016 but most of this increase was driven by
increase in all age groups of males (combined annualized percentage change
(APC) 9.2%, p-value <0.001), females 45-64 yo (APC 7.8%, p-value
<0.001) and females ≥65 yo (APC 7.4%, p-value <0.001).
Incidence in females 18-44 yo remained unchanged over time. Conclusion:
CVT incidence is disproportionately higher in blacks compared to other
races. New CVT hospitalizations increased significantly over the last
decade mainly in males and older females. Further studies are needed to
determine whether this increase represents true increase from changing
risk factors or artefactual increase from improved detection.