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Characterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling

ChEBI2015-10-31 更新2026-07-12 收录

小分子药物表征

Keap1-Nrf2信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-71695 数据链接链接失效反馈

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Characterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling

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2015-10-31

蛋白质晶体结构解析

Keap1-Nrf2信号通路

Crystal Structure of Keap1 in Complex with phosphorylated p62 Descriptor: Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1 Authors: Fukutomi, T, Takagi, K, Mizushima, T, Tanaka, K, Kom

Protein Data Bank Japan2024-11-13 更新270

Meta-analysis: Sulforaphane reno-protective effects in animal models of kidney diseases

药物肾保护作用

Keap1-Nrf2信号通路

Research question: Does Sulforaphane present any reno-protective effects in pre-clinical animal models of kidney disease ? Context and rationale: Chronic kidney disease (CKD) is characterized by the

NIAID Data Ecosystem60

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane treated human breast epithelial cells. Homo sapiens

乳腺癌化学预防

Keap1-Nrf2信号通路

Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a potent inhibitor of experimental mammary carcinogenesis and may be an effective, safe chemopreventive agent for use in human

NIAID Data Ecosystem40

Data_Sheet_1_Antiaging function of Chinese pond turtle (Chinemys reevesii) peptide through activation of the Nrf2/Keap1 signaling pathway and its structure-activity relationship.docx

抗氧化肽

Keap1-Nrf2信号通路

Chinese pond turtle is a traditional nourishing food with high nutritional value and bioactivity and has been considered a dietary remedy for prolonging the lifespan since ancient times. However, only

NIAID Data Ecosystem70

Expression data from Keap1 overexpression and Nrf2 knockdown lung cancer cell

基因表达谱分析

Keap1-Nrf2信号通路

Keap1 overexpressed and Nrf2 depleted CL1-5 cells were used to identify genes regulated by Keap1/Nrf2 axis-dependent gene regulations We used microarrays to detail the global programme of gene express

NIAID Data Ecosystem50

Characterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling

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