scRNA-seq data from: DJ-1 inhibition reshapes tumor microenvironment and potentiates immune checkpoint inhibitors

This dataset contains raw single-cell RNA sequencing data generated from
tumor-infiltrating CD45⁺ immune cells in murine cancer models to
investigate the role of DJ-1 (PARK7) in modulating anti-tumor immunity. In
the associated study, genetic ablation of DJ-1 enhanced the efficacy of
immune checkpoint blockade by indirectly activating T cells through
macrophage reprogramming. Loss of DJ-1 increased reactive oxygen species
(ROS) levels in macrophages and promoting differentiation into Cxcl9⁺
immune-stimulatory phenotypes while reducing Spp1⁺ immune-suppressive
subsets. Here, we deposited additional raw sequencing reads in FASTQ
format from sorted CD45⁺ cells (DJ-1 knockout and wild-type
conditions).  A detailed description of experimental procedures
and analysis workflows can be found in the associated publication.