Transcriptomic analysis of the effect of carvacrol on Klebsiella pneumoniae.

The effect of arvacrol on the HVKP strain AP8555 and the CRKP strain S270 was analysed using a transcriptomic approach. The inhibitory effect of carvacrol was mainly attributed to (i) down-regulation of plasmid transfer gene expression, including the mating pair formation (Mpf) system and the DNA transfer and replication (Dtr) system, due to reduced adenosine triphosphate (ATP) energy supply, (ii) the decreased contact between donor and acceptor cells and formation of adhesive pilus.