Additional file 3 of Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Additional file 3: Table S3. KMT2D essentiality network results. A. Ranked list of genes in the KMT2D essentiality network. GeneName: hugo gene symbol. GeneNameID: hugo gene symbol separated by NCBI gene id. Estimate: Pearson’s correlation coefficient. P.value: p-value derived from Pearson’s correlation test. Perm.adj.p.value: p-values corrected for multiple testing using permutation tests with 100,000 random sampling. Rank: rank in list determined by order of estimate. Candidate_inflection: TRUE if a gene’s Pearson’s correlation coefficient is past the inflection point of the positive/negative curve (see Methods). Chr: chromosome location of gene. Gene_start_bp: a gene’s start position. Gene_end_bp: a gene’s end position. Karyotype_band: the karyotype band in which the gene is found. B. Enriched GO biological processes found among co-/anti-essential genes. Results are outputs from ClusterProfiler. C. Clustered GO terms of co-essential genes.