Comparing the whole genome methylation landscape of dairy calf blood cells revealed potential intergenerational inheritance of the maternal metabolic status

Whole genome methylation of the daughters' blood cells was assessed by Whole Genome Bisulfite Sequencing (WGBS), revealed the whole epigenetic landscape of calf blood cells, suggesting that the maternal metabolic status can indeed affect the embryo's epigenetic status and metabolic related pathways in offspring, providing further evidence for epigenetic intergenerational inheritance of metabolic stress in domestic animals Overall design: methylation profile of eight daughter descended from metabolic stessed cow