Whole-genome sequencing and intestinal metagenome sequencing revealed the carriage and transmission of Salmonella in Xinjiang, China

A total of 31 Salmonella enterica strains were isolated from salmonellosis cases in Urumqi, Xinjiang. Whole-genome sequencing (WGS) was performed to identify serotypes, antimicrobial resistance genes, and virulence genes. Additionally, metagenomic sequencing was conducted on 50 randomly selected fecal samples from 2000 healthy individuals to analyze microbial community differences, prevalence of Salmonella and other pathogenic bacteria, and their associated characteristic microorganisms.