Cell cultures were isolated from primary pancreatic cancers (PPTs) of KPC mice and subjected to array comparative genomic habridization (aCGH) for the investigation of copy nummber profiles. We genera
It is becoming clear that copy number polymorphism in the human genome is a significant form of genetic variation. We have developed a new method that uses SNP genotype data from parent-offspring trio
Entries in the table indicate the proportion of times (out of 125 observations in each category) that top-down segmentation outperforms the bottom-up approach. Values smaller than (highlighted) indica
To assess whether specific genes have relevant somatic genetic or epigenetic alterations in ectopic tissue, we used a combined analysis of transcriptome (confirmed by qRT-PCR on 68 genes), methylome,
