mRNA expression profiles analysis of crocin mitigated triptolide-induced toxicity in mouse liver tissues

Clinical use of triptolide (TP) is restricted due to severe toxicity. This study assessed the protective effect of crocin (CR) as a natural antioxidant against TP-induced toxicity. Mouse Liver tissues were selected from the Control, MTP, and MTP+CR groups for transcriptome studies. Overall design: The mice were randomly placed in the following 3 groups (n=4): A. Normal saline (NC); B. 300µg/kg Moderate-dose TP (MTP); C. 300µg/kg Moderate-dose TP + 100 mg/kg CR (MTP+CR); The mice were administrated the treatments daily via oral gavage for 7 days at a volume of 0.2 ml/10 g per dose.