Analysis of the brain metastasis-associated microenvironment in different preclinical models of brain metastasis

To investigate the potential similarities and differences within the brain microenvironment among three different models of orthotopic implanted brain metastatic cell lines Gene expression profiling analysis using data obtained from RNA-seq of 6 brains per experimental model was performed Comparative gene expression profiling analysis of RNA-seq data of the brain metastasis-associated microenvironment (resection of the peritumoral area) of the lung cancer brain metastasis model 482N1, the breast cancer brain metastasis model E0771-BrM and the melanoma brain metastasis model B16/F10-BrM (n=6 brains per model)