Supplementary Table 3 from Novel Afro-Caribbean Prostate Cancer Model Reveals Ancestry-Specific Drug Vulnerabilities with Therapeutic Implications for Black Patients

DEGs: Black-derived vs White-derived PCa Lines. This table documents the 633 genes differentially expressed between Black-derived (ACRJ-PC28 and MDA-PCA-2b) and White-derived (DU-145 and PC-3) PCa cell lines. The data includes gene identifiers, annotations, expression fold changes, statistical significance values, and functional pathway associations. The table highlights genes consistently underexpressed in Black-derived cell lines, including TNFRSF14 and other genes involved in androgen signaling, DNA damage repair, and growth factor pathways that may contribute to the observed ancestry-dependent differences in drug sensitivity, particularly to androgen-targeted therapies and PARP inhibitors.