Comparison of 21 scoring functions on PDBbind v2007 core set ( = 195).

Pearson's correlation coefficient , Spearman's correlation coefficient and standard deviation of the difference between predicted and experimental binding affinity on PDBbind v2007 core set ( = 195). The scoring functions are sorted in the descending order of . RF-Score, AutoDock Vina and idock rank 1st, 7th and 8th respectively in terms of Pearson's correlation coefficient . RF-Score, ID-Score, SVR-Score and X-Score are the only scoring functions whose training set do not overlap with the PDBbind v2007 core set. The statistics for AutoDock Vina and idock are reported in this study and the statistics for the other 19 scoring functions are collected from [31], [45], [46], [48].