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Data for: Discovery of 5-Naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines.

NIAID Data Ecosystem2026-03-11 收录

HDAC抑制剂

白血病药物筛选

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Structural Characterization data of synthesized derivatives

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创建时间：

2019-12-31

HDAC抑制剂

肽类药物化学

Natural, nonribosomal cyclotetrapeptides have traditionally been a rich source of inspiration for design of potent histone deacetylase (HDAC) inhibitors. We recently disclosed the total synthesis and

Figshare2016-02-16 更新60

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T‑Cell Prolymphocytic Leukemia

HDAC抑制剂

白血病靶向治疗

Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current

NIAID Data Ecosystem40

Vascular histone deacetylation by pharmacological HDAC inhibition [SAHA, ChIP-seq]

血管胆管表观遗传学

HDAC抑制剂

HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is th

NIAID Data Ecosystem30

Effects of PKC412 and KIN001-102, alone and combined, on MOLM14-luc+ cell cycle progression (following 24 hours of treatment) and apoptosis (following 48 hours of treatment) when cells are cultured in the presence of 50% HS-5 SCM.

白血病药物筛选

细胞周期与凋亡

Details of the assays used for these studies are provided in the Materials and Methods section.

NIAID Data Ecosystem50

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates

HDAC抑制剂

表观遗传药物化学

The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new

NIAID Data Ecosystem30

Data for: Discovery of 5-Naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines.

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