Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

ChEBI2014-09-11 更新2026-07-21 收录

表观遗传重编程

甲基化组学动态分析

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-56650 数据链接链接失效反馈

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Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

创建时间：

2014-09-11

Trichostatin A does not correct specific errors of somatic cell nuclear transfer on the transcriptomic level; highlighing the non-random nature of oocyte-mediated reprogramming errors.

动物克隆胚胎

表观遗传重编程

Bovine cloned and IVF blastocysts at day 7 were collected and used for comparative transcriptomics. A potent histone deacetylase inhibitor, Trichostatin A (TSA), was used to understand the effect of

NIAID Data Ecosystem60

Dppa2/4 Counteract De Novo Methylation to Establish a Permissive Epigenome for Development [CRISPR]

表观遗传重编程

CRISPRi筛选

Early mammalian development entails widespread epigenome remodeling, including DNA methylation erasure and reacquisition, which facilitates developmental competence. To uncover the mechanisms that orc

NIAID Data Ecosystem60

HIF-1 directly induces TET3 expression to redistribute 5-hydroxymethylcytosine and induce erythroid gene expression in hypoxia [RNA-seq]. HIF-1 directly induces TET3 expression to redistribute 5-hydroxymethylcytosine and induce erythroid gene expression in hypoxia [RNA-seq]

红细胞生成低氧应答

表观遗传重编程

We performed RNA-sequencing on erythropoietic cells cultured in normoxia or hypoxia at days 3,7, and 10. We found numerous expression changes induced by hypoxia, including the canonical hypoxia target

NIAID Data Ecosystem40

MeDIP-seq on heart tissues from AMI mouse models

疾病表观遗传学

甲基化组学动态分析

Alterations of DNA methylation modification in heart tissues of AMI mouse models at series of time points (Sham, AMI 10-min, 1-hr, 6-hr, 24-hr and 72-hr)

NIAID Data Ecosystem60

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

受精卵DNA去甲基化

表观遗传重编程

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential.

NIAID Data Ecosystem50

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

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