KAP1 negatively regulates Pol II elongation kinetics to activate signal-induced transcription

NIAID Data Ecosystem2026-05-02 收录

转录调控机制

RNA聚合酶II动力学

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https://data.mendeley.com/datasets/ffsbjbkkvx 数据链接链接失效反馈

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These are westerns blots corresponding to 5 figures in figure 1.

创建时间：

2024-06-07

ABCD2 Is a Direct Target of β -Catenin and TCF-4: Implications for X-Linked Adrenoleukodystrophy Therapy

基因治疗研究

转录调控机制

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC) transporter subfamily D member 1 protein (

NIAID Data Ecosystem30

BHLHE40 is key hypoxia-induced transcriptional repressor in beta cells. BHLHE40 is key hypoxia-induced transcriptional repressor in beta cells

细胞缺氧反应

转录调控机制

To assess the impact of hypoxia on global gene expression of beta cells, we performed bulk RNA-seq on mouse islets, human islets and MIN6 cells. Bhlhe40 was transcriptional repressor which was highly

NIAID Data Ecosystem20

Knockdown effect of CDK8 or CDK19 in HeLa S3 cell. Homo sapiens

基因功能验证

转录调控机制

Mediator complex has been known as pivotal regulator of RNA polymerase II. Mediator complex has two CDK subunits in vertebrates, named CDK8 and CDK19. To elucidate functional difference between CDK8 a

NIAID Data Ecosystem10

Structure of transcription regulator CcpA in its DNA-free state

蛋白质结构解析

转录调控机制

Structure of transcription regulator CcpA in its DNA-free state

NIAID Data Ecosystem20

PIF4/HEMERA-mediated daytime thermosensory growth requires the Mediator subunit MED14. PIF4/HEMERA-mediated daytime thermosensory growth requires the Mediator subunit MED14

植物热形态建成

转录调控机制

Warm ambient temperatures do not trigger stress responses in plants but stimulate the growth of specific organs. The basic helix-loop-helix transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (PIF4)

NIAID Data Ecosystem10

KAP1 negatively regulates Pol II elongation kinetics to activate signal-induced transcription

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