A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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TGFbeta inhibition via CRISPR promotes the long-term efficacy of CAR-T cells against solid tumors
In recent years, CAR-T cell therapy has proven to be a promising approach against cancer. Nonetheless, this approach still faces multiple challenges in eliminating solid tumors, one of which being the
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CRISPR activation screen to identify X-chromosomal Xist activators in male embryonic stem cells. CRISPR activation screen to identify X-chromosomal Xist activators in male embryonic stem cells
As the master regulator of X-chromosome inactivation (XCI), the Xist RNA is expressed nearly ubiquitously in female mice. Xist is only absent in the germ line and at the pluripotent state. Xist is gen
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UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]. UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]
Using pooled shRNA libraries we performed a focused screen of 115 genes in 3D ex vivo cultures of primary murine lung tumor cells and 2D cultures of murine LKR10 cells. These screens identify Uhrf1 as
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Trypanosoma brucei genome-wide RNAi library screen of raltitrexed
The aim of this study was to identify and characterise mechanisms of resistance to antifolate drugs in African trypanosomes. A genome-wide RNAi library screen was undertaken in bloodstream form Trypan
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Listeria monocytogenes gene essentiality under laboratory conditions and during macrophage infection. Listeria monocytogenes gene essentiality
The Gram-positive bacterium Listeria monocytogenes occurs widespread in the environment and infects humans when ingested along with contaminated food. Such infections are particularly dangerous for ri
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