Baseline characteristics of study population.

PurposeRight ventricular (RV) dysfunction remains a major long-term complication in patients with repaired Tetralogy of Fallot (rTOF). While cardiac magnetic resonance (CMR) is the gold standard for right ventricular (RV) assessment, it is limited by accessibility and cost. Three-dimensional echocardiography (3DE), with its strain imaging capabilities, offers a promising alternative for the serial evaluation of right ventricular (RV) size and function. This study aims to compare RV volumetric and myocardial deformation parameters obtained by 2D and 3D echocardiography (2DE, 3DE) with RV function measured by CMR in patients with rTOF.Materials and MethodsWe retrospectively analyzed 43 patients with rTOF who underwent same day 2D, 3D echocardiography, and CMR between November 2023 and December 2024. RV volumes, ejection fraction (RVEF), and global longitudinal strain (GLS) were measured across modalities. Correlation, Bland-Altman analysis, and area under receiver operating characteristic (AUC) curves were used to evaluate the agreement and diagnostic accuracy for detecting right ventricular (RV) systolic dysfunction.ResultsThree-DE demonstrated a strong correlation with CMR for RVEDV (r = 0.95) and RVEDVi (r = 0.91), with a mild underestimation. RVEF by 3DE was significantly lower than CMR (46.4 ± 8.8% vs. 50.3 ± 7.3%, p = 0.002). RV-GLS values differed across modalities, with 3DE yielding more negative values than 2DE (−20.3 ± 4.4% vs. −18.5 ± 4.7%, p = 0.009). Among patients with CMR-RVEF ConclusionThree-dimensional echocardiography demonstrates a consistent association with CMR for the assessment of right ventricular volumes but modest underestimation of volumetric and functional parameters. Abnormal right ventricular strain was observed in patients with CMR-defined systolic dysfunction, supporting the clinical relevance of strain analysis. Overall, 3DE may serve as a feasible complementary tool for longitudinal right ventricular assessment in patients with rTOF, alongside CMR as the reference standard.