Transcriptomic profile of Pdk2KO mice treated with RGLS4326

Kidney global mRNA expression profiles was carried out in the Pkd2-KO model following RGLS4326 treatment PBS-treated controls. We found that RGLS4326 treatment had a significant transcriptome-wide impact and globally de-repressed mRNAs of predicted miR-17 target genes in cystic kidneys of Pkd2-KO model Overall design: Pkd2-KO mice were randomly assigned and dosed with RGLS4326 (20 mg kg-1) or PBS by SC injections at post natal day (P)10, 11,12 and 19. Non-transgenic strain-matched mice were used for comparison. All animals were euthanized, and kidney harvested at P28 .