Transcriptomic profiling of BMAL1-silenced HBE cells under HDM stimulation

This study investigates the transcriptomic changes in human bronchial epithelial cells (HBE135) following stimulation with house dust mite (HDM) extract and BMAL1 knockdown. The experiment includes two groups: (1) HBE135 cells treated with HDM alone and (2) HBE135 cells transfected with siRNA targeting BMAL1 followed by HDM stimulation. The RNA-seq data aim to explore the role of BMAL1 in modulating airway epithelial responses to allergic stimuli and provide insights into circadian regulation in asthma-related inflammation.