Radiotelemetric and HRV parameters in response to the restraint test.

Values are reported as means ± SEM of data obtained by averaging multiple 3-min segments acquired in baseline conditions (30 min), during the restraint (15 min) and the recovery phase (45 min) in Fto+/+ (n = 8) and Fto−/− mice (n = 12). Abbreviations: HRV = heart rate variability; HR = heart rate; RMSSD = square root of the mean squared differences of successive RR intervals; HF = high-frequency; LF = low-frequency; T = body temperature; LOC = locomotor activity. * and # indicate a significant difference between Fto+/+ and Fto−/− mice (p<0.05 and p<0.01, respectively).