Regulation of gene expression in ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE25118
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资源简介：
To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK. Mice bearing NCI-H2228 cells were orally administered at dose of 0 (vehicle), 4 or 20 mg/kg of CH5424802, and the tumors were collected and lysed at 6 hours post-dose. Total RNA were extracted from xenograft tumors.
创建时间：
2019-03-25
