Methionine de novo and salvage pathway

Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway Pathway adapted from [http://www.kegg.jp/kegg-bin/show_pathway?map00270 KEGG]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3580 CPTAC Assay Portal]

蛋氨酸作为一种必需氨基酸，动物体内无法自行合成。在细菌和植物中，蛋氨酸由天冬氨酸合成[MD:M00017]。由蛋氨酸和ATP合成的S-腺苷蛋氨酸（SAM）是众多重要转移反应中的甲基供体，包括DNA甲基化以调控基因表达。SAM亦可用于在蛋氨酸再生途径中再生蛋氨酸。此途径改编自[http://www.kegg.jp/kegg-bin/show_pathway?map00270 KEGG]。该途径上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP3580 CPTAC 测定门户]获得靶向检测。