Table_2_Psychiatric Symptomatology, Mood Regulation, and Resting State Functional Connectivity of the Amygdala: Preliminary Findings in Youth With Mood Disorders and Childhood Trauma.docx

BackgroundAs mood dysregulation and hyperarousal are overlapping and prominent features of posttraumatic stress disorder (PTSD), and mood disorders (MD) including bipolar disorder (BD), we aimed to clarify the role of trauma and MD on the resting state functional connectivity (RSFC) of amygdala in MD youth with or without trauma exposure, and healthy controls (HC).MethodsOf 23 subjects, 21 completed the magnetic resonance imaging (MRI) protocol, 5 were excluded for subject motion, leaving final sample size of 16: nine subjects with MD (5/9 with trauma), and 7 HC. Youth were assessed with Schedule for Affective Disorders and Schizophrenia for School Aged Children—Present and Lifetime Version (K-SADS-PL), and other behavioral measures including Young Mania Rating Scale (YMRS). Imaging data were acquired using functional MRI in 3-T scanner. Imaging included T1-weighted structural MRI and 6-min resting state acquisition.ResultsIn between group analysis, the average correlation coefficients between left anterior cingulate cortex (Acc) and left insula cortex with left amygdala regions were significantly larger in HC compared to the patient population. Connectivity between left amygdala and left cingulate cortex shows a significant negative correlation with YMRS severity.ConclusionsIn this preliminary study, MD with trauma youth had more manic symptoms and difficulties regulating anger. While MD youth showed reduced RSFC of left amygdala with left acc and left insula, no significant difference between the subgroups of children with MD was observed. However, when looking at both clinical groups together, we observed a significant correlation of RSFC of left amygdala to left acc, and YMRS scores.

背景：情绪失调与过度唤醒是创伤后应激障碍（PTSD）以及包括双相情感障碍（BD）在内的情绪障碍（MD）的共同且突出的特征。本研究旨在阐明创伤和情绪障碍对MD青少年及其是否暴露于创伤的环境中杏仁核的静息态功能连接（RSFC）的作用，以及与健康对照者（HC）。方法：在23名受试者中，21名完成了磁共振成像（MRI）方案，5名因受试者运动被排除，最终样本量为16名：9名MD患者（其中5名有创伤史）和7名HC。青少年使用儿童和青少年精神分裂症及相关障碍评定量表（K-SADS-PL）以及包括年轻男性躁狂评定量表（YMRS）在内的其他行为评估。在3.0T扫描仪上使用功能性核磁共振成像（fMRI）获取成像数据。成像包括T1加权结构MRI和6分钟的静息态采集。结果：在组间分析中，与健康对照组相比，患者组左侧前扣带回皮层（Acc）与左侧杏仁核区域之间的平均相关系数显著更大。左侧杏仁核与左侧扣带回皮层之间的连接性与YMRS严重程度呈显著负相关。结论：在本初步研究中，MD且有创伤史的青少年表现出更多的躁狂症状和愤怒调节困难。MD青少年显示出左侧杏仁核与左侧扣带回皮层和左侧岛叶皮层之间的RSFC减少，但在MD儿童亚组之间未观察到显著差异。然而，当同时考虑两组临床群体时，我们观察到左侧杏仁核的RSFC与左侧扣带回皮层和YMRS评分之间存在显著相关性。