MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE192976
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资源简介：
Analysis of ferroptosis markers from cells isolated from neuroblastoma orthotopic xenograft mouse model. We combine simultaneous inhibition of cysteine uptake and transsulfuration in xenograft model using SK-N-DZ cell line. We treated the mice with IKE and PPG together with genetic targeting of GPX4 activity. At the end of the treatment, transcriptional profiling of residual small tumors revealed induction of ferroptosis markers after combined inhibition of cystine uptake/cysteine synthesis and GPX4 as compared to tumors treated with vehicle control. 5 samples were analyzed in each group
创建时间：
2022-05-02
