Total Synthesis of Alanense A through an Intramolecular Friedel–Crafts Alkylation
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https://figshare.com/articles/dataset/Total_Synthesis_of_Alanense_A_through_an_Intramolecular_Friedel_Crafts_Alkylation/25029472
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资源简介：
The first total synthesis of cadinane sesquiterpenoid
alanense
A, in which an intramolecular dehydrative Friedel–Crafts alkylation
of 2,5-diaryl-2-pentanol is incorporated as a key step, has been achieved.
The combinatorial use of p-TsOH·H2O as a catalyst and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a
solvent provides 1,1-disubstituted tetrahydronaphthalene in 97% yield.
It was also found that the combination of p-TsOH
and HFIP is effective for the removal of phenolic MOM ether.
创建时间：
2024-01-19
