TIPE1 regulation on macrophage polarization. TIPE1 regulation on macrophage polarization

Macrophages perform key and distinct functions in maintaining tissue homeostasis through finely tuning their polarization state.Here, we found that tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) was highly expressed in macrophages and Tipe1 depletion impeded M2 polarization of macrophages. The goals of this study are to compare BMDMs from LyzM-Cre; Tipe1f/f or Tipe1f/f mice to have a further view of the potential difference. Overall design: Examination of 2 different bone marrow derived macrophages from LyzM-Cre; Tipe1f/f or Tipe1f/f mice respectively